Anodal tDCS applied to the left frontal cortex abrogates scopolamine-induced fear memory deficit via the dopaminergic system

Evidence suggests that transcranial direct current stimulation (tDCS) modulates conditioned fear memories and has effects on cognitive flexibility via the dopaminergic system. This study examines whether modulation of scopolamine-induced memory deficit by anodal tDCS could be mediated The male NMRI mice received scopolamine, 30 min before conditioning, showed impaired contextual retention. Mice subjected to left frontal for 20 or min, retrieval. Anodal application significantly decreased scopolamine response retention, while one applied did not alter. Moreover, abolished deficit. Dopaminergic antagonists SCH23390 sulpiride, alone in combination, prevented abolishment effect deficit, whereas they alter impairing at dose 2 mg/kg. Our data suggest abrogates influence antagonists, indicating involvement system